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Chinese Journal of Digestive SurgerySeptember 2018,Vol.17,No.9Forum for Experts

Controversy and consensus of the anti-tumor necrosis factor alpha in the treatment of Crohn¡äs disease with intestinal stricture

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¡¾Abstract¡¿

The emergence of the antitumor necrosis factor alpha (anti-TNF-α) therapies has brought lots of benefits to patients with inflammatory bowel disease (IBD). However, controversies exist over whether anti-TNF-α could be used for Crohn′s disease (CD) patients with intestinal stricture. Some articles found stricturing CD patients under anti TNF therapy had a high risk of intestinal obstruction or even perforation while others found that there was no association between anti-TNF-α and intestinal obstruction. The fundamental cause lies in that anti-TNF-α only target at inflammation, but cannot be resistant to intestinal fibrosis or change long term outcome. To avoid and prevent intestinal obstruction or perforation, authors should evaluate the component and type of intestinal stricture cautiously before starting anti-TNF-α therapy. Exploring new specific anti fibrotic therapy will be a promising way for all stricturing CD patients.

Author£ºYu Qiao,Li Qinghai,Song Yongmao,Xu Dong,Chen Yan
Work unit£ºDepartment of Gastroenterology, Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou 310000, China
DOI£º10.3760/cma.j.issn.1673-9752.2018.09.006

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Journal Information

Responsible Information

China Association for Science and Technology

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Chinese Medical Association

Editing

Editorial Board of Chinese Journal of Digestive Surgery
29 Gaotanyan, Shapingba, Chongqing 400038, China
Tel: 0086-23-68754655
Fax: 0086-23-65317637
Email: digsurg@zhxhwk.com

Editor-in-Chief

DONG Jia-hong

Managing Director

CHEN Min

Publishing

Chinese Medical Journals
Publishing House Co., Ltd.

Overseas Distributor

China International Book Trading Corportation

CSSN

ISSN 1673-9752
CN 11-5610/R